'The Big Bang Theory' has been a huge part of American household for years. Throughout it's run several characters came and went, and some casting decision made by the show's producers hurt the show and some of them helped it. Screenrant listed a few of these castings they noticed. They believe Amy Farrah Fowler playing Mayim Bialik hurt the show, not because of her acting but because her character didn't help the show. One casting they said helped the show was Kaley Cuoco as Penny. They say she gave the show warmth and real heart.