Fox's Deadpool 2 brought in $125m this weekend.
Deadpool 2 now has the second-highest opening ever for an R-rated movie.
Deadpool 2 ended the three-week reign of Disney's Avengers: Infinity War at the top of the North American box office.
The film fell somewhat short of the $130 million the studio predicted.
2016's Deadpool earned $132.4m tin it's opening weekend two years ago.
Deadpool 2 grossed $176.3m internationally.